Tilly was part of a gene therapy clinical trial at Sheffield Children's Hospital in 2024 to try to help reduce seizures connected to her condition.
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The problem gets worse in pipelines. When you chain multiple transforms — say, parse, transform, then serialize — each TransformStream has its own internal readable and writable buffers. If implementers follow the spec strictly, data cascades through these buffers in a push-oriented fashion: the source pushes to transform A, which pushes to transform B, which pushes to transform C, each accumulating data in intermediate buffers before the final consumer has even started pulling. With three transforms, you can have six internal buffers filling up simultaneously.
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